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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Neurogenomics
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1466278
Genetic overlap between multi-site chronic pain and cognition: a large-scale genome-wide cross-trait analysis
Provisionally accepted- 1 Second Xiangya Hospital, Central South University, Changsha, China
- 2 Sun Yat-sen University, Guangzhou, Guangdong Province, China
- 3 Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian Province, China
In this work, we conducted a large genome-wide association summary statistics (GWAS) to investigate the pleiotropic associations between cognition and multi-site chronic pain in single nucleotide polymorphism (SNP) levels, and gene levels and explore the biological pathways. We also employed a latent causal variable model (LCV) to examine the causal relationship between the two traits finally, the role of genes on the phenotype at the transcriptional level is discussed. This was the first article to systematically examine the link between cognition and multi-site chronic pain from a genetic perspective, and it demonstrated the occurrence and development of mental disorders from a biological standpoint.
Keywords: Pain, Cognition, Genetic architecture, genetic correlation, GWAS
Received: 17 Jul 2024; Accepted: 21 Feb 2025.
Copyright: © 2025 Chen, Deng, Zhang, Wang and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xuegao Yu, Sun Yat-sen University, Guangzhou, 510275, Guangdong Province, China
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