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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Autonomic Neuroscience
Volume 19 - 2025 | doi: 10.3389/fnins.2025.1424629
Use of Nasal Mucosal Autonomic Nerve Response in Efficacy Evaluation of Vidian Neurectomy for Allergic Rhinitis：A Prospective Study
Provisionally accepted- 1 The First People’s Hospital of Yulin, Yulin, China
- 2 Yan 'an University, Yan 'an, China
Objective: To evaluate the use of nasal mucosal autonomic nerve responses as an objective indicator for assessing the efficacy of vidian neurectomy (VN) in treating allergic rhinitis (AR).Methods: Thirty-five patients with moderate to severe AR and 35 healthy controls were included. Autonomic nerve responses were measured before and 1 month after VN surgery, using respiratory stimulation on the nasal mucosa and the opisthenar area. Three waveform types (P-type, N-type and M-type) were identified.Results: While three waveform types were identified in the nasal mucosa, only the M-type was observed in the opisthenar sympathetic skin response. Preoperative measurements showed higher autonomic responses in patients with AR compared with controls. Following VN, the responses in patients with AR decreased significantly, aligning closely with the control group. No significant changes were observed in the opisthenar responses, indicating a localised effect of VN. Comorbidities such as nasal polyps, sinusitis and deviated septum did not impact the results.Nasal mucosal autonomic nerve response provides a reliable, objective measure for evaluating the effectiveness of VN in treating AR.
Keywords: allergic rhinitis, Vidian nerve, Nasal Mucosal Autonomic Nerve Response, sympathetic skin response, waveform
Received: 12 Jun 2024; Accepted: 10 Mar 2025.
Copyright: © 2025 Liu, Ma, Niu, Peng, Li, Shen, He and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yan Niu, The First People’s Hospital of Yulin, Yulin, China
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