Skip to main content

MINI REVIEW article

Front. Neurosci.
Sec. Neurogenesis
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1529855

Neural differentiation in perspective: mitochondria as early programmers

Provisionally accepted
Ramin M Farahani Ramin M Farahani *
  • The University of Sydney, Darlington, Australia

The final, formatted version of the article will be published soon.

    Neural differentiation during development of the nervous system has been extensively studied for decades. These efforts have culminated in the generation of a detailed map of developmental events that appear to be associated with emergence of committed cells in the nervous system. In this review the landscape of neural differentiation is revisited by focusing on abiotic signals that play a role in induction of neural differentiation. Evidence is presented regarding a chimeric landscape whereby abiotic signals generated by mitochondria orchestrate early events during neural differentiation. This early stage, characterised by mitochondrial hyperactivity, in turn triggers a late stage of differentiation by reprogramming the activity of biotic signals.

    Keywords: Mitochondria, neural differentiation, electron transport chain, Redox (bio)geochemistry, Thermal signal

    Received: 17 Nov 2024; Accepted: 23 Dec 2024.

    Copyright: © 2024 M Farahani. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ramin M Farahani, The University of Sydney, Darlington, Australia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.