Yan Wei ^* Li Chen ^*

• North Sichuan Medical College, Nanchong, China

Subcortical ischemic vascular disease (SIVD) is a major cause of vascular cognitive impairment (CI) and dementia. We aimed investigate dynamic functional connectivity (dFC) in subcortical ischemic vascular disease (SIVD), with a focus on the temporal and spatial properties of functional connectivity (FC) and their relationship with CI using restingstate functional MRI (rs-fMRI).Across all groups, the dFC analyses revealed two distinct states: State II (65. 18%) was a more segregated brain state with a preponderance of within-network connections, while State I (34.82%) was an integrated state with highly connected functional internetwork components.State II was 70. 13% more common in SIVD than in HCs, but State I was proportionately less common. Additionally, SIVD patients exhibited a much lower number of transitions (NT) between states and stayed in State II for a significantly longer period of time than HCs.Patients with SIVD-CI spent more time in State II than those with SIVD-NC in the SIVD subgroup. According to the correlation study, longer duration and more instances of State II in SIVD patients were linked to poorer cognitive function.Reduced NT between states and higher occurrences and stay duration in the segregated state were among the altered temporal features that defined the CI in SIVD. DFC may offer helpful indicators to detect cognitive impairment in SIVD populations and aid in a better understanding of pathology associated with SIVD.