Skip to main content

MINI REVIEW article

Front. Neurosci.
Sec. Neuroendocrine Science
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1500353

Involvement of the parabrachial nucleus in emergence from general anesthesia

Provisionally accepted
Jia Li Jia Li 1*Qiuyu Zhu Qiuyu Zhu 2Jiaxin Xiang Jiaxin Xiang 3Yiyong Wei Yiyong Wei 4*Donghang Zhang Donghang Zhang 5*
  • 1 Xi'an Honghui Hospital, Xi'an, Shaanxi Province, China
  • 2 Longgang District People's Hospital of Shenzhen, Shenzhen, China
  • 3 Weill Cornell Medicine, Cornell University, New York, New York, United States
  • 4 Shantou University, Shantou, Guangdong Province, China
  • 5 West China Hospital, Sichuan University, Chengdu, China

The final, formatted version of the article will be published soon.

    The parabrachial nucleus (PBN), located in the dorsolateral pons, is involved in many important biological functions, such as sensory signaling, feeding, defensive behaviors, fear, anxiety, and sleep-wake cycles. General anesthesia shares the classical feature of reversible loss of consciousness with natural sleep, and accumulating evidence has indicated that general anesthesia and sleep-wake behaviors share some common underlying neural mechanism. In recent years, emerging studies have investigated the involvement of PBN in emergence from general anesthesia, but divergence exists in terms of different types of general anesthetics or different durations of treatment with the same group of general anesthetics. Here, we reviewed the current literature and summarized the evidence about the contribution of PBN to general anesthesia.

    Keywords: parabrachial nucleus, PBN, general anesthesia, General Anesthetics, review

    Received: 24 Sep 2024; Accepted: 27 Nov 2024.

    Copyright: © 2024 Li, Zhu, Xiang, Wei and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jia Li, Xi'an Honghui Hospital, Xi'an, Shaanxi Province, China
    Yiyong Wei, Shantou University, Shantou, 515063, Guangdong Province, China
    Donghang Zhang, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.