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REVIEW article
Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1499458
This article is part of the Research Topic Myeloid Cells as Active Players in Human Neurodegenerative Diseases View all articles
More than microglia: Myeloid cells and biomarkers in neurodegeneration Authors
Provisionally accepted
Eleftheria Kodosaki
1*
Rosie Bell
1
Aitana Sogorb-Esteve
1
Katharine Wiltshire
1
Henrik Zetterberg
1,2
Amanda Heslegrave
1*- 1 University College London, London, United Kingdom
- 2 University of Gothenburg, Gothenburg, Västergötland, Sweden
neurodegenerative diseases, and the recent advances in biofluid and imaging myeloid biomarker research with a focus on methods that can be used in the clinic. For this review, evidence from three neurodegenerative diseases will be included, Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). We discuss the potential for these biomarkers to be used in humans with suspected NDD as prognostic, diagnostic, or monitoring tools, identify knowledge gaps in literature, and propose potential approaches to further elucidate the role of myeloid cells in neurodegeneration and better utilise myeloid biomarkers in the understanding and treatment of NDD.
Keywords: myeloid, biomarkers, neurodegeneration, Microglia, Myeloid Cells
Received: 20 Sep 2024; Accepted: 16 Oct 2024.
Copyright: © 2024 Kodosaki, Bell, Sogorb-Esteve, Wiltshire, Zetterberg and Heslegrave. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Eleftheria Kodosaki, University College London, London, United Kingdom
Amanda Heslegrave, University College London, London, United Kingdom
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.