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CASE REPORT article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1483587

Drug-induced Parkinsonism in a patient with DiGeorge Syndrome: A Case Report

Provisionally accepted
Clancy Cerejo Clancy Cerejo Nicolas De Cleene Nicolas De Cleene Gerald Walser Gerald Walser Atbin Djamshidian Atbin Djamshidian Klaus Seppi Klaus Seppi Beatrice Heim Beatrice Heim *
  • Innsbruck Medical University, Innsbruck, Austria

The final, formatted version of the article will be published soon.

    DiGeorge syndrome, also referred as 22q11.2 deletion syndrome is a multisystem disorder associated with an increased risk of early-onset parkinsonism. In this case report, we present a case of a 47-year-old male patient with complex comorbidities and seizures. This patient presented with increased seizure frequency and on examination was found to have parkinsonism. Due to the symptoms constellation a genetic analysis was done which revealed 2 presence of DiGeorge syndrome. However, his DaTscan was normal and hence a possibility of medication induced parkinsonism was considered. Through this case report we want to emphasize the fact that while it is important to consider genetic testing for young patients with parkinsonism especially in those with complex comorbidities, other possible causes of parkinsonism should not be ignored.

    Keywords: DiGeorge Syndrome, parkinsonism, Lamotrigine, early- onset, Drug induced

    Received: 20 Aug 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 Cerejo, De Cleene, Walser, Djamshidian, Seppi and Heim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Beatrice Heim, Innsbruck Medical University, Innsbruck, Austria

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