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HYPOTHESIS AND THEORY article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1479830
This article is part of the Research Topic Neuroinflammation and Neurodegenerative Diseases View all 11 articles

The potential role of CGRP in synuclein-associated neurodegenerative disorders

Provisionally accepted
Athanasia Alexoudi Athanasia Alexoudi 1,2*VIncenzo Donadio VIncenzo Donadio 3Elissaios Karageorgiou Elissaios Karageorgiou 2
  • 1 National and Kapodistrian University of Athens, Athens, Greece
  • 2 Neurological Institute of Athens, Athens, Greece
  • 3 IRCCS Institute of Neurological Sciences of Bologna (ISNB), Bologna, Emilia-Romagna, Italy

The final, formatted version of the article will be published soon.

    In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of α-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.

    Keywords: CGRP, synuclein-associated neurodegenerative disorders, Neuroinflammation, GLP-1, Apoptosis, Neuromodulation

    Received: 12 Aug 2024; Accepted: 21 Oct 2024.

    Copyright: © 2024 Alexoudi, Donadio and Karageorgiou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Athanasia Alexoudi, National and Kapodistrian University of Athens, Athens, Greece

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.