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SYSTEMATIC REVIEW article

Front. Neurosci.
Sec. Brain Imaging Methods
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1474780

Predictive value of radiomics for intracranial aneurysm rupture: a systematic review and meta-analysis

Provisionally accepted
Haoda Wang Haoda Wang 1Haidong Xu Haidong Xu 1Junsheng Fan Junsheng Fan 1Jie Liu Jie Liu 1Liangfu Li Liangfu Li 1Zailiang Kong Zailiang Kong 1Hui Zhao Hui Zhao 2*
  • 1 Department of Radiology, The First Hospital of Huhhot, Huhhot 010030, Inner Mongolia Autonomous Region, China, Huhhot, China
  • 2 Department of Radiotherapy,Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010030, Inner Mongolia Autonomous Region, China, Huhhot, China

The final, formatted version of the article will be published soon.

    Objective: To systematically review the literature on radiomics for predicting intracranial aneurysm rupture and conduct a meta-analysis to obtain evidence confirming the value of radiomics in this prediction.: A systematic literature search was conducted in PubMed, Web of Science, Embase, and The Cochrane Library databases up to March 2024. The QUADAS-2 tool was used to assess study quality. Stata 15.0 and Review Manager 5.4.1 were used for statistical analysis.Outcomes included combined sensitivity (Sen), specificity (Spe), positive likelihood ratio (+LR), negative likelihood ratio (-LR), diagnostic odds ratio (DOR), and their 95% confidence intervals (CI), as well as pre-test and post-test probabilities. The SROC curve was plotted, and the area under the curve (AUC) was calculated. Publication bias and small-study effects were assessed using the Deeks' funnel plot.The 9 included studies reported 4,284 patients, with 1,411 patients with intracranial aneurysm rupture (prevalence 32.9%). The overall performance of radiomics for predicting intracranial aneurysm rupture showed a combined Sen of 0.78 (95% CI: 0.74-0.82), Spe of 0.74 (95% CI: 0.70-0.78), +LR of 3.0 (95% CI: 2.7-3.4), -LR of 0.29 (95% CI: 0.25-0.35), DOR of 10 (95% CI: 9-12), and AUC of 0.83 (95% CI: 0.79-0.86). Significant heterogeneity was observed in both Sen (I 2 =90.93%, 95% CI: 89.00-92.87%) and Spe (I 2 =94.28%, 95% CI: 93.21-95.34%).Radiomics can improve the diagnostic efficacy of intracranial aneurysm rupture.More large-sample, prospective, multicenter clinical studies are needed to further evaluate its predictive value.

    Keywords: Radiomics, intracranial aneurysm rupture, Meta-analysis, systematic review, diagnosis

    Received: 02 Aug 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Wang, Xu, Fan, Liu, Li, Kong and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Zhao, Department of Radiotherapy,Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010030, Inner Mongolia Autonomous Region, China, Huhhot, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.