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REVIEW article

Front. Neurosci.
Sec. Translational Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1467562
This article is part of the Research Topic Central Nervous System Diseases and Anesthesia View all 6 articles

Neddylation of protein, a new strategy of protein post-translational modification for targeted treatment of central nervous system diseases

Provisionally accepted
Qian Wu Qian Wu 1Ziang Geng Ziang Geng 2Jun Lu Jun Lu 3Shisong Wang Shisong Wang 3Zhongxue Yu Zhongxue Yu 4Siqi Wang Siqi Wang 5Shu Guan Shu Guan 6*Tiancong Liu Tiancong Liu 7*Chen Zhu Chen Zhu 3*
  • 1 Department of Neurology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
  • 2 Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China
  • 3 Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, China
  • 4 Department of Cardiovascular Ultrasound, First Affiliated Hospital of China Medical University, Shenyang, China
  • 5 Department of Radiation Oncology, First Affiliated Hospital of China Medical University, Shenyang, China
  • 6 Department of Surgical Oncology and Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, China
  • 7 Department of Otolaryngology, Shengjing Hospital of China Medical University, Shenyang, China

The final, formatted version of the article will be published soon.

    Neddylation, a type of protein post-translational modification that links the ubiquitin-like protein NEDD8 to substrate proteins, can be involved in various significant cellular processes and generate multiple biological effects. Currently, the best-characterized substrates of neddylation are the Cullin protein family, which is the core subunit of the Cullin-RING E3 ubiquitin ligase complex and controls many important biological processes by promoting ubiquitination and subsequent degradation of various key regulatory proteins. The normal or abnormal process of protein neddylation in the central nervous system can lead to a series of occurrences of normal functions and the development of diseases, providing an attractive, reasonable, and effective targeted therapeutic strategy. Therefore, this study reviews the phenomenon of neddylation in the central nervous system and summarizes the corresponding substrates. Finally, we provide a detailed description of neddylation involved in CNS diseases and treatment methods that may be used to regulate neddylation for the treatment of related diseases.

    Keywords: Neddylation, Central Nervous System, Neurology, Glioma, targeted therapy

    Received: 20 Jul 2024; Accepted: 17 Oct 2024.

    Copyright: © 2024 Wu, Geng, Lu, Wang, Yu, Wang, Guan, Liu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Shu Guan, Department of Surgical Oncology and Breast Surgery, First Affiliated Hospital of China Medical University, Shenyang, China
    Tiancong Liu, Department of Otolaryngology, Shengjing Hospital of China Medical University, Shenyang, China
    Chen Zhu, Department of Neurosurgery, First Affiliated Hospital of China Medical University, Shenyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.