Skip to main content

ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Neuroscience Methods and Techniques
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1465642

Multi-Level Feature Fusion Network for Neuronal Morphology Classification

Provisionally accepted
  • University of Science and Technology of China, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    Neuronal morphology can be represented using various feature representation methods, such as hand-crafted morphometrics and deep features. These features are complementary to each other, contributing to improving performance. However, existing classification methods only utilize a single feature representation or simply concatenate different features without considering complementary information. Therefore, their performance is limited and can be further improved.In this paper, we propose a multi-level feature fusion network that fully utilizes diverse feature representations and their complementary information to describe neuronal morphology effectively. Specifically, we devise a Multi-Level Fusion Module (MLFM) and incorporate it into each feature extraction block. It can facilitate the interaction between different features and achieve effective feature fusion at multiple levels. The MLFM comprises a channel attention-based Feature Enhancement Module (FEM) and a cross-attention-based Feature Interaction Module (FIM). The FEM is used to enhance robust morphological feature presentations, while the FIM mines and propagates complementary information across different feature presentations. In this way, our feature fusion network ultimately yields a more distinctive neuronal morphology descriptor that can effectively characterize neurons than any singular morphological representation. Experimental results show that our method effectively depicts neuronal morphology and correctly classifies 10type neurons on the NeuronMorpho-10 dataset with an accuracy of 95.18%, outperforming other approaches. Moreover, our method performs well on the NeuronMorpho-12 and NeuronMorpho-17 datasets and possesses good generalization.

    Keywords: Cross attention, Feature fusion, Multi-level fusion, Neuronal morphology, neuron classification

    Received: 16 Jul 2024; Accepted: 03 Oct 2024.

    Copyright: © 2024 Sun and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Chunli Sun, University of Science and Technology of China, Hefei, 230026, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.