Nurul Akmal Che Lah
Nava Shmoel
Sonia Trigueros- 1Centre for Advanced Intelligent Materials, Universiti Malaysia Pahang Al-Sultan Abdullah, Gambang, Pahang, Malaysia
- 2Faculty of Manufacturing and Mechatronics Engineering Technology, Universiti Malaysia Pahang Al-Sultan Abdullah, Pekan, Pahang, Malaysia
- 3McGovern Institute for Brain Research, MIT, Cambridge, MA, United States
- 4Department of Genetics Microbiology and Statistics, University of Barcelona, Barcelona, Spain
Editorial on the Research Topic
Smart nano-architectures for neuroscience and neuroengineering: from properties to applications
Nanotechnology, with its innovations in nanoarchitecture, has emerged as a powerful tool for addressing major global challenges. From revolutionizing healthcare to bolstering food security, its potential is vast. Despite these advancements, numerous unresolved issues remain, particularly concerning their potential role in supporting cancer development and progression. The scientific pursuit is complex, with researchers investigating whether a unified theory could link continuum/molecular-level quantum mechanics with neural circuitry theory. Such a theory would provide a crucial framework for further safe and effective enhancements in performance.
This Research Topic represents collective efforts in neuroscience and recent advanced smart nanoarchitecture technologies, addressing various key concerns in both fields. A recent advancement is the use of nanoarchitecture for the precise diagnosis of Glioblastoma multiforme (GBM), the most aggressive type of brain glioma, as presented by Wei et al. Studies comparing organic nanomaterials known for their high biocompatibility and biodegradability, such as liposomes, polymer nanoparticles, and extracellular vesicles, have demonstrated promising prospects for clinical use. This review acknowledges the challenges in developing effective functional organic nanomaterials for GBM treatment and emphasizes the need to scale up production and address ethical issues related to nanotechnology.
In a case-control study, Macintosh et al. explored the effects of leukodystrophy-associated Pol III subunits on the migration, proliferation, differentiation, and myelination processes during oligodendrocyte maturation. The study revealed that reduced Pol III activity hindered the differentiation of these precursor cells into mature oligodendrocytes. The findings provide insight into the role of Pol III in oligodendrocyte development and shed light on the pathophysiological mechanisms underlying hypomyelination in POLR3-related leukodystrophy.
Maeng et al. explored the use of adrenal magnetothermal stimulation via magnetic nanoparticle (MNP) technology to study changes in the stress-induced hypothalamic-pituitary-adrenal axis and sympathoadrenal-medullary system. This approach demonstrated MNP-triggered adrenal release, evidenced by changes in physiological (heart rate) and serum markers (epinephrine and corticosterone) before and after conditioning. Beyond their application for probing peripheral organ function, magnetic nanomaterials have been increasingly recognized for their therapeutic and “theranostic” potential.
Khan et al. investigated the use of diosgenin, a natural compound, as an anti-inflammatory agent that also targets cancer and cancer-induced inflammation. They assessed the efficacy of Tween 80 (P80)-coated stearic acid solid lipid nanoparticles (SLNPs) encapsulating diosgenin in terms of stability, monodispersity, and entrapment efficiency, evaluating their potential as both anticancer and antidepressant agents. The study highlighted the use of diosgenin-incorporated SLNPs for enhancing grooming behavior and social interaction without any signs of toxicity. Further research is required to fully establish the safety profile of diosgenin and to evaluate the effectiveness of SLNPs in targeting specific conditions.
Author contributions
NACL: Writing – original draft, Writing – review & editing. NS: Writing – review & editing. ST: Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Keywords: nanoarchitectures, nanotechnology, neuroscience, diagnosis, theranostic
Citation: Che Lah NA, Shmoel N and Trigueros S (2024) Editorial: Smart nano-architectures for neuroscience and neuroengineering: from properties to applications. Front. Neurosci. 18:1462078. doi: 10.3389/fnins.2024.1462078
Received: 09 July 2024; Accepted: 15 July 2024;
Published: 31 July 2024.
Edited and reviewed by: Laura Ballerini, International School for Advanced Studies (SISSA), Italy
Copyright © 2024 Che Lah, Shmoel and Trigueros. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Nurul Akmal Che Lah, akmalcl@umpsa.edu.my