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ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Neuropharmacology
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1454369
This article is part of the Research Topic Therapeutics and Clinical Management of Neurological Disorders: Exploring Novel Approaches and Biomarkers of Vulnerability View all 4 articles

Cathepsins and neurological diseases: a Mendelian randomization study

Provisionally accepted
Haitao Sun Haitao Sun 1青青 Tang 青青 Tang 1Xue Yan Xue Yan 2*Wanying Xie Wanying Xie 1Yueshan Xu Yueshan Xu 1*Weimin Zhang Weimin Zhang 1*
  • 1 Changchun University of Chinese Medicine, Changchun, China
  • 2 The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Hebei Province, China

The final, formatted version of the article will be published soon.

    The causal relationship between cathepsins and neurological diseases remains uncertain. To address this, we utilized a two-sample Mendelian randomization (MR) approach to assess the potential causal effect of cathepsins on the development of neurological diseases.This study conducted a two-sample two-way MR study using pooled data from published genome-wide association studies to evaluate the relationship between 10 cathepsins (cathepsins B, D, E, F, G, H, L2, O, S, and Z) and 7 neurological diseases, which included ischemic stroke, cerebral hemorrhage, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, and epilepsy.The analysis employed various methods such as inverse variance weighting (IVW), weighted median, MR Egger regression, MR pleiotropy residual sum and outlier, Cochran Q statistic, and leave-one-out analysis.We found a causal relationship between cathepsins and neurological diseases, including Cathepsin B and Parkinson's disease (IVW odds ratio (OR): 0.89, 95%

    Keywords: Cathepsin, Neurological Diseases, Mendelian randomization, risk, genetic associations

    Received: 25 Jun 2024; Accepted: 24 Sep 2024.

    Copyright: © 2024 Sun, Tang, Yan, Xie, Xu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xue Yan, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Hebei Province, China
    Yueshan Xu, Changchun University of Chinese Medicine, Changchun, China
    Weimin Zhang, Changchun University of Chinese Medicine, Changchun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.