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MINI REVIEW article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1451845
This article is part of the Research Topic Neurobiological underpinnings of neurodegenerative and neuropsychiatric disorders: from models to therapy View all 7 articles

A Review of MPTP-Induced Parkinsonism in Adult Zebrafish to Explore Pharmacological Interventions for Human Parkinson's Disease

Provisionally accepted
Emmeline Bagwell Emmeline Bagwell Jessica Larsen Jessica Larsen *
  • Clemson University, Clemson, United States

The final, formatted version of the article will be published soon.

    Novel work in adult zebrafish, Danio rerio, to recapitulate human neurodegenerative disease has proven useful in both pharmaceutical development and research on genetic disease.Due to high genetic homology to humans, affordable husbandry, relatively quick life cycle breeding times, and robust embryo production, zebrafish offer a promising model to test pharmaceutical performance in a high throughput, in vivo setting. Currently, most research in zebrafish models of Parkinson's Disease induces the disease during larval or embryonic stage organisms due to ease of administration, with advancement through developmental stages taking only a matter of days 1 . The use of early-stage organisms limits the usability of zebrafish as models for adult disease and specifically age-related neurodegenerative conditions. Recently, researchers have sought to extend the usability of zebrafish into models for Parkinson's Disease. Specifically, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has emerged as a prodrug that upon injection well-encompasses the biochemical mechanisms and symptomology associated with Parkinson's Disease. By utilizing MPTP in an adult zebrafish model, advancements in Parkinson's Disease research may be achieved. This paper highlights the recent research on this model, comparing it to the human form of Parkinson's Disease.

    Keywords: Zebrafish, parkinsonism, Animal Models, neurodegeneration, MPTP

    Received: 19 Jun 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Bagwell and Larsen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jessica Larsen, Clemson University, Clemson, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.