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ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Neural Technology
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1448365

Analyzing the Transient Response Dynamics of Long-term Depression in the Mouse Auditory Cortex in vitro through Multielectrode-arraybased Spatiotemporal Recordings

Provisionally accepted
Ryo Furukawa Ryo Furukawa 1Kouta KUME Kouta KUME 2Takashi Tateno Takashi Tateno 3*
  • 1 Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan
  • 2 Hokkaido University, Sapporo, Japan
  • 3 Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan

The final, formatted version of the article will be published soon.

    In the auditory cortex, synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD), plays crucial roles in information processing and adaptation to the auditory environment. Previous rodent studies have shown life-long cortical map plasticity, even beyond the critical period of development. While thalamocortical synapses exhibit LTD during the critical period, however, little is known about LTD in cortico-cortical connections of the adult mouse auditory cortex. Here, we investigated the transient response dynamics of LTD in layers 2 to 5 of the mouse auditory cortex following tetanic stimulation (TS) to layer 4. To characterize LTD properties, we developed a recording protocol to monitor activity levels at multiple sites, including those more than 0.45 mm from the TS site. This allowed us to distinguish LTD-induced reductions in neural excitability from other types, including neural activity depletion. Our findings revealed that LTD induced in layer 4 persisted for over 40 minutes post-TS, indicating robust cortico-cortical LTD. Using electrophysiological data and a modified synaptic model, we identified key receptors involved in synaptic plasticity and their effects on response dynamics, proposing a method for studying LTD in the mature mouse auditory cortex. Particularly, by employing a simple dynamical model, we analyzed and discussed the involvement of key receptors during the transient period of LTD. This study expands our understanding of synaptic plasticity in the mature mouse auditory cortex beyond the critical period, potentially informing future treatments for hearing disorders.

    Keywords: Auditory Cortex, Electric Stimulation, multielectrode array, high-frequency stimulation, Local cortical network, Long-term depression, spatiotemporal neural plasticity

    Received: 13 Jun 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Furukawa, KUME and Tateno. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Takashi Tateno, Faculty of Information Science and Technology, Hokkaido University, Sapporo, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.