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ORIGINAL RESEARCH article
Front. Neurosci.
Sec. Perception Science
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1445727
This article is part of the Research Topic Elucidating the Relationships between Pupil Size and Neural and Autonomic Functions View all 4 articles
Age-related changes in pupil dynamics and task modulation across the healthy lifespan
Provisionally accepted- 1 Centre for Neuroscience Studies, Faculty of Health Sciences, Queen's University, Kingston, Canada
- 2 School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, Canada
- 3 Eye-Tracking Laboratory, Department of Anesthesiology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- 4 Department of Anesthesiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
The pupil is modulated by luminance, arousal, bottom-up sensory, and top-down cognitive signals, and has increasingly been used to assess these aspects of brain functioning in health and disease. However, changes in pupil dynamics across the lifespan have not been extensively examined, hindering our ability to fully utilize the pupil in probing these underlying neural processes in development and aging in healthy and clinical cohorts. Here, we examined pupil responses during the interleaved pro-/anti-saccade task (IPAST) in healthy participants across the lifespan (n = 567, 5-93 years of age). Based on the extracted measurements of pupil dynamics, we demonstrated age-related changes in pupil measures and task modulation. Moreover, we characterized the underlying factors and age-related effects in components of pupil responses that may be attributed to developmental and aging changes in the associated brain regions. Finally, correlations between factors of pupil dynamics and saccade behaviours revealed evidence of shared neural processes in the pupil and saccade control circuitries. Together, these results demonstrate changes in pupil dynamics as a result of development and aging, providing a baseline with which altered pupil responses due to neurological deficits at different ages can be studied.
Keywords: Pupillary Response, development, Aging, Saccade preparation, anti-saccade
Received: 08 Jun 2024; Accepted: 28 Oct 2024.
Copyright: © 2024 Huang, Smorenburg, Yep, Riek, Calancie, Kirkpatrick, Brien, Coe, Wang and Munoz. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jeff Huang, Centre for Neuroscience Studies, Faculty of Health Sciences, Queen's University, Kingston, Canada
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