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ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1440118

Exposure to biodiesel exhaust is less harmful than exposure to mineral diesel exhaust on blood-brain barrier integrity in a murine model

Provisionally accepted
Michael L. Nesbit Michael L. Nesbit 1Colleen K. Ko Colleen K. Ko 1John C. Mamo John C. Mamo 1Virginie Lam Virginie Lam 1Katherine R. Landwehr Katherine R. Landwehr 2,3Alexander Larcombe Alexander Larcombe 1,2Ryusuke Takechi Ryusuke Takechi 1*
  • 1 School of Public Health, Faculty of Health Science, Curtin University, Perth, WA, Australia
  • 2 Telethon Kids Institute, University of Western Australia, Nedlands, Western Australia, Australia
  • 3 Curtin University, Perth, Western Australia, Australia

The final, formatted version of the article will be published soon.

    Emerging data suggest that air pollution is a persistent source of neuroinflammation, reactive oxygen species (ROS), and neuropathology that contributes to central nervous system (CNS) disorders. Previous research using animal models has shown that exposure to diesel exhaust causes considerable disruption of the blood-brain barrier (BBB), leading to marked neuroinflammation. However, the effects of biodiesel exhaust on cerebrovascular integrity and neuroinflammation have not been explored previously. Therefore, in this study, 8-weekold BALB/c mice were exposed to biodiesel exhaust (derived from canola biodiesel or tallow biodiesel) and compared with control mice that were exposed to air or mineral diesel exhaust.Consistently with previous findings, the integrity of the BBB was significantly disrupted by exposure to mineral diesel exhaust. Tallow and canola biodiesel exhaust exposure resulted in no BBB disruption. Moreover, both tallow and canola biodiesels significantly attenuated oxidative stress in the brain. The data collectively suggest that biodiesel exhaust may exert significantly less detrimental effects on brain function, compared to mineral diesel.

    Keywords: Air Pollution, diesel exhaust, biodiesel exhaust, Blood -brain barrier, Neuroinflammation

    Received: 29 May 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Nesbit, Ko, Mamo, Lam, Landwehr, Larcombe and Takechi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Ryusuke Takechi, School of Public Health, Faculty of Health Science, Curtin University, Perth, 6102, WA, Australia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.