Skip to main content

REVIEW article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1439055

A Review of the Roles of Pathogens in Alzheimer's Disease

Provisionally accepted
Meng Zhao Meng Zhao Yongchun Wang Yongchun Wang Yanxin Shen Yanxin Shen Chunxiao Wei Chunxiao Wei Gui M. Zhang Gui M. Zhang Li Sun Li Sun *
  • Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchcun, China

The final, formatted version of the article will be published soon.

    Alzheimer's disease (AD) is one of the leading causes of dementia and is characterized by memory loss, mental and behavioral abnormalities, and impaired ability to perform daily activities. Even as a global disease that threatens human health, effective treatments to slow the progression of AD have not been found, despite intensive research and significant investment. In recent years, the role of infections in the etiology of AD has sparked intense debate. Pathogens invade the central nervous system through a damaged blood-brain barrier or nerve trunk and disrupt the neuronal structure and function as well as homeostasis of the brain microenvironment through a series of molecular biological events. In this review, we summarize the various pathogens involved in AD pathology, discuss potential interactions between pathogens and AD, and provide an overview of the promising future of anti-pathogenic therapies for AD.

    Keywords: Alzheimer's disease, Bacterial infection, Fungal Infection, pathogen, viral infection

    Received: 27 May 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Zhao, Wang, Shen, Wei, Zhang and Sun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Li Sun, Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchcun, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.