AUTHOR=Kisliouk Tatiana , Ravi Padma Malini , Rosenberg Tali , Meiri Noam 

TITLE=Embryonic manipulations shape life-long, heritable stress responses through complex epigenetic mechanisms: a review

JOURNAL=Frontiers in Neuroscience

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1435065

DOI=10.3389/fnins.2024.1435065

ISSN=1662-453X

ABSTRACT=<p>Enhancing an organism’s likelihood of survival hinges on fostering a balanced and adaptable development of robust stress response systems. This critical process is significantly influenced by the embryonic environment, which plays a pivotal role in shaping neural circuits that define the stress response set-point. While certain embryonic conditions offer advantageous outcomes, others can lead to maladaptive responses. The establishment of this response set-point during embryonic development can exert life-long and inheritable effects on an organism’s physiology and behavior. This review highlights the significance of multilevel epigenetic regulation and the intricate cross-talk among these layers in response to heat stress during the embryonic period, with a particular focus on insights gained from the avian model.</p>