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REVIEW article
Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1434945
This article is part of the Research Topic Tissue Culture to Clinical Relevance: Brain Organoids to Investigate Brain Disorders Rooted in Aging and Development View all 4 articles
Modeling Alzheimer's Disease Using Human Cell Derived Brain Organoids and 3D Models
Provisionally accepted
Sarah Fernandes
1,2
Jasmin Revanna
1,2
Joshua Pratt
1,3
Nick Hayes
1,4*
Maria C. Marchetto
1,2*
Fred H. Gage
1*- 1 Salk Institute for Biological Studies, La Jolla, United States
- 2 University of California, San Diego, La Jolla, California, United States
- 3 San Diego State University, San Diego, California, United States
- 4 California State University San Marcos, San Marcos, California, United States
Age-related neurodegenerative diseases, like Alzheimer's disease (AD), are challenging diseases for those affected with no cure and limited treatment options. Functional, human derived brain tissues that represent the diverse genetic background and cellular subtypes contributing to sporadic AD (sAD) are limited. Human stem cell derived brain organoids recapitulate some features of human brain cytoarchitecture and AD-like pathology, providing a tool for illuminating the relationship between AD pathology and neural cell dysregulation leading to cognitive decline. In this review, we explore current strategies for implementing brain organoids in the study of AD as well as the challenges associated with investigating age-related brain diseases using organoid models.
Keywords: brain organoids, Alzheimer's disease, Aging, Neurodegenerative Diseases, APOE, Amyloid beta, Hyperphosphorylated tau, cerebral organoids
Received: 19 May 2024; Accepted: 10 Jul 2024.
Copyright: © 2024 Fernandes, Revanna, Pratt, Hayes, Marchetto and Gage. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Nick Hayes, Salk Institute for Biological Studies, La Jolla, United States
Maria C. Marchetto, University of California, San Diego, La Jolla, 92093, California, United States
Fred H. Gage, Salk Institute for Biological Studies, La Jolla, United States
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