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REVIEW article

Front. Neurosci.
Sec. Neuropharmacology
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1428085

Influencing Factors of Glymphatic System During Perioperative Period

Provisionally accepted
Rui Dong Rui Dong 1,2,3Wenjie Liu Wenjie Liu 2Yuqiang Han Yuqiang Han 1Zimo Wang Zimo Wang 1Linhao Jiang Linhao Jiang 1Liwei Wang Liwei Wang 4*Xiaoping Gu Xiaoping Gu 1*
  • 1 Medical School of Nanjing University, Department of Anesthesiology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China
  • 2 Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao, Shandong Province, China
  • 3 Key Laboratory of Anesthesiology and Resuscitation, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
  • 4 Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, China

The final, formatted version of the article will be published soon.

    The glymphatic system is a functional cerebrospinal fluid circulatory system that uses peri-arterial space for inflow of cerebrospinal fluid and peri-venous space for efflux of cerebrospinal fluid from brain parenchyma. This brain-wide fluid transport pathway facilitates the exchange between cerebrospinal fluid and interstitial fluid and clears metabolic waste from the metabolically active brain. Multiple lines of work show that the glymphatic system is crucial to normal brain functions, and the dysfunction of the glymphatic system is closely associated with various neurological disorders, including aging, neurodegeneration, and acute brain injury. Currently, it is common to explore the functional and molecular mechanisms of the glymphatic system based on animal models. The function of glymphatic system during perioperative period is affected by many factors such as physiological, pathological, anesthetic and operative methods. To provide a reference for the interpretation of the results of glymphatic system studies during perioperative period, this article comprehensively reviews the physiological and pathological factors that interfere with the function of the glymphatic system during perioperative period, investigates the effects of anesthetic drugs on glymphatic system function and the potential underlying mechanisms, describes operative methods that interfere with the function of the glymphatic system, and potential intervention strategies based on the glymphatic system. Future, these variables should be taken into account as critical covariates in the design of functional studies on the glymphatic system.

    Keywords: Glymphatic system, Perioperative, Anesthetic drugs, Physiology, Pathology, AQP4, Cerebrospinal Fluid

    Received: 23 May 2024; Accepted: 23 Aug 2024.

    Copyright: © 2024 Dong, Liu, Han, Wang, Jiang, Wang and Gu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Liwei Wang, Department of Anesthesiology, Xuzhou Central Hospital, Xuzhou, China
    Xiaoping Gu, Medical School of Nanjing University, Department of Anesthesiology, Nanjing Drum Tower Hospital, Nanjing, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.