XiXi Zhao ^1* Su Ziyao ² Haoran Zhang ³ Yingtan Wang ¹ BingXu Chen ⁴ Zhizhen Zhang ⁵ Bin Wang ¹ Jun Liu ¹ Yuwei Shi ^2*

• ¹ Beijing Anding Hospital, Capital Medical University, Beijing, China
• ² Xinjiang Medical University, Ürümqi, Xinjiang Uyghur Region, China
• ³ Capital Medical University, Beijing, Beijing Municipality, China
• ⁴ Faculty of Information Technology, Beijing University of Technology, Beijing, China
• ⁵ School of Mathematical Sciences, East China Normal University, Shanghai, China

Bipolar disorder ( BD ) is a severe psychiatric disease with high rates of misdiagnosis and underdiagnosis, resulting in a significant disease burden on both individuals and society. Abnormal neural oscillations have garnered significant attention as potential neurobiological markers of BD. However, untangling the mechanisms that subserve these baseline alternations requires measurement of their electrophysiological underpinnings. This systematic review investigates consistent abnormal resting-state EEG power of BD and conducted an initial exploration into how methodological approaches might impact the study outcomes. This review was conducted in Pubmed-Medline and Web-of-Science in March 2024 to summarize the oscillation changes in resting-state EEG (rsEEG) of BD. We focusing on rsEEG to report spectral power in different frequency bands. We identified 10 studies, in which neural oscillations was compared with healthy individuals (HCs). We found that BD patients had abnormal oscillations in delta, theta, beta, and gamma bands, predominantly characterized by increased power, indicating potential widespread neural dysfunction, involving multiple neural networks and cognitive processes.However, the outcomes regarding alpha oscillation in BD were more heterogeneous, which is thought to be potentially influenced by the disease severity and the diversity of samples. Furthermore, we conducted an initial exploration into how demographic and methodological elements might impact the study outcomes, underlining the importance of implementing standardized data collection methods. Key aspects we took into account included gender, age, medication usage, medical history, the method of frequency band segmentation, and situation of eye open/eye close during the recordings. Therefore, in the face of abnormal multiple oscillations in BD, we need to adopt a comprehensive research approach, consider the multidimensional attributes of the disease and the heterogeneity of samples, and pay attention to the standardized experimental design to improve the reliability and reproducibility of the research results.