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REVIEW article

Front. Neurosci.
Sec. Translational Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1424316
This article is part of the Research Topic Impacts of 2021 WHO Classification on the Precise Diagnosis and Management of Gliomas, Volume II View all articles

Advances in Diffuse Glioma Assessment: Preoperative and Postoperative Applications of Chemical Exchange Saturation Transfer

Provisionally accepted
Hua Zhen Deng Hua Zhen Deng 1Han-wen Zhang Han-wen Zhang 2Fan Lin Fan Lin 2*YI LEI YI LEI 3*jin huan deng jin huan deng 2*si ping luo si ping luo 2*xiao lei liu xiao lei liu 2*
  • 1 Shantou University, Shantou, China
  • 2 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
  • 3 Shenzhen Samii International Medical Center, Shenzhen, China

The final, formatted version of the article will be published soon.

    Chemical Exchange Saturation Transfer (CEST) is a technique that uses specific offresonance saturation pulses to pre-saturate targeted substances. This process influences the signal intensity of free water, thereby indirectly providing information about the pre-saturated substance. Among the clinical applications of CEST, Amide Proton Transfer (APT) is currently the most well-established. APT can be utilized for the preoperative grading of gliomas. Tumors with higher APTw signals generally indicate a higher likelihood of malignancy. In predicting preoperative molecular typing, APTw values are typically lower in tumors with favorable molecular phenotypes, such as Isocitrate dehydrogenase (IDH) mutations, compared to IDH wild-type tumors. For differential diagnosis, the average APTw values of meningiomas are significantly lower than those of high-grade gliomas. Various APTw measurement indices assist in distinguishing central nervous system lesions with similar imaging features, such as progressive multifocal leukoencephalopathy, central nervous system lymphoma, solitary brain metastases, and glioblastoma. Regarding prognosis, APT effectively differentiates between tumor recurrence and treatment effects, and also possesses predictive capabilities for overall survival (OS) and progression-free survival (PFS).

    Keywords: Amide proton transfer imaging, adult-type diffuse glioma, Preoperative diagnosis, postoperative assessment, precision medicine

    Received: 27 Apr 2024; Accepted: 16 Jul 2024.

    Copyright: © 2024 Deng, Zhang, Lin, LEI, deng, luo and liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fan Lin, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
    YI LEI, Shenzhen Samii International Medical Center, Shenzhen, China
    jin huan deng, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
    si ping luo, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
    xiao lei liu, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.