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REVIEW article
Front. Neurosci.
Sec. Translational Neuroscience
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1424316
This article is part of the Research Topic Impacts of 2021 WHO Classification on the Precise Diagnosis and Management of Gliomas, Volume II View all articles
Advances in Diffuse Glioma Assessment: Preoperative and Postoperative Applications of Chemical Exchange Saturation Transfer
Provisionally accepted- 1 Shantou University, Shantou, China
- 2 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
- 3 Shenzhen Samii International Medical Center, Shenzhen, China
Chemical Exchange Saturation Transfer (CEST) is a technique that uses specific offresonance saturation pulses to pre-saturate targeted substances. This process influences the signal intensity of free water, thereby indirectly providing information about the pre-saturated substance. Among the clinical applications of CEST, Amide Proton Transfer (APT) is currently the most well-established. APT can be utilized for the preoperative grading of gliomas. Tumors with higher APTw signals generally indicate a higher likelihood of malignancy. In predicting preoperative molecular typing, APTw values are typically lower in tumors with favorable molecular phenotypes, such as Isocitrate dehydrogenase (IDH) mutations, compared to IDH wild-type tumors. For differential diagnosis, the average APTw values of meningiomas are significantly lower than those of high-grade gliomas. Various APTw measurement indices assist in distinguishing central nervous system lesions with similar imaging features, such as progressive multifocal leukoencephalopathy, central nervous system lymphoma, solitary brain metastases, and glioblastoma. Regarding prognosis, APT effectively differentiates between tumor recurrence and treatment effects, and also possesses predictive capabilities for overall survival (OS) and progression-free survival (PFS).
Keywords: Amide proton transfer imaging, adult-type diffuse glioma, Preoperative diagnosis, postoperative assessment, precision medicine
Received: 27 Apr 2024; Accepted: 16 Jul 2024.
Copyright: © 2024 Deng, Zhang, Lin, LEI, deng, luo and liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fan Lin, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
YI LEI, Shenzhen Samii International Medical Center, Shenzhen, China
jin huan deng, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
si ping luo, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
xiao lei liu, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
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