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ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Neurodegeneration
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1417178

Near-Infrared Light Stimulation Regulates Neural Oscillation and Memory Behavior of Mice with Alzheimer's Disease

Provisionally accepted
Song Zhang Song Zhang Honglei Jiao Honglei Jiao *Xiaopeng Wang Xiaopeng Wang
  • Second Hospital of Hebei Medical University, Shijiazhuang, China

The final, formatted version of the article will be published soon.

    Photobiomodulation (PBM) is a non-invasive neuromodulation technique for the brain.Low-intensity near-infrared light (1-500mw) has demonstrated the ability to improve memory in Alzheimer's disease (AD) model mice, suggesting its potential for AD treatment. However, the impact of PBM on neural oscillations in the hippocampal region affected by AD remains unknown. In this study, AD model mice were subjected to PBM for 60 days and then tested using novel object recognition behavior (NOR) experiments.During behavioral experiments, local field potential signals (LFP) of the mice was recorded using a single electrode in the CA1 region to analyze memory ability and neural oscillation characteristics. The results revealed that mice stimulated with PBM exhibited significantly higher new object differentiation indices compared to the Sham group (p<0.01). Furthermore, PBM stimulation led to a significant increase in relative power and sample entropy of theta and gamma bands (p<0.01). The coupling intensities of θlow-γ and θ-high-γ were also significantly higher in the PBM group compared to the Sham group (p<0.01).In conclusion, these findings suggest that PBM may improve memory ability in AD mice through regulation of neural oscillation characteristics, providing a theoretical basis for utilizing PBM as a treatment modality for Alzheimer's disease.

    Keywords: Alzheimer's disease, photobiomodulation, Electroencephalogram, Neural oscillations, near-infrared light stimulation

    Received: 14 Apr 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Zhang, Jiao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Honglei Jiao, Second Hospital of Hebei Medical University, Shijiazhuang, China

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