AUTHOR=Wu Yongjiang , Wang Yanfei , Lu Yunchi , Yan Junguo , Zhao Hongjun , Yang Riyun , Pan Jingying 

TITLE=Research advances in huntingtin-associated protein 1 and its application prospects in diseases

JOURNAL=Frontiers in Neuroscience

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1402996

DOI=10.3389/fnins.2024.1402996

ISSN=1662-453X

ABSTRACT=<p>Huntingtin-associated protein 1 (HAP1) was the first protein discovered to interact with huntingtin. Besides brain, HAP1 is also expressed in the spinal cord, dorsal root ganglion, endocrine, and digestive systems. HAP1 has diverse functions involving in vesicular transport, receptor recycling, gene transcription, and signal transduction. HAP1 is strongly linked to several neurological diseases, including Huntington’s disease, Alzheimer’s disease, epilepsy, ischemic stroke, and depression. In addition, HAP1 has been proved to participate in cancers and diabetes mellitus. This article provides an overview of HAP1 regarding the tissue distribution, cell localization, functions, and offers fresh perspectives to investigate its role in diseases.</p>