Huiyan Lin ^1* Maximilian Bruchmann ^2,3 Sebastian Schindler ^2,3 Thomas Straube ^2,3*

• ¹ Guangdong University of Finance, Guangzhou, China
• ² Institute of Medical Psychology and Systems Neuroscience, Faculty of Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany
• ³ Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, Münster, North Rhine-Westphalia, Germany

Faces can acquire emotional meaning by learning to associate individuals with specific behaviors. Here, we investigated emotional evaluation and brain activations toward faces of persons who had given negative or positive evaluations to others. Furthermore, we investigated how emotional evaluations and brain activation generalize to perceptually similar faces. Valence ratings indicated learning and generalization effects for both positive and negative faces. Brain activation, measured with functional magnetic resonance imaging (fMRI), showed significantly increased activation in the fusiform gyrus (FG) to negatively associated faces but not positively associated ones. Remarkably, brain activation in FG to faces to which emotional meaning (negative and positive) was successfully generalized was decreased compared to neutral faces. This suggests that the emotional relevance of faces is not simply associated with increased brain activation in visual areas. While, at least for negative conditions, faces paired with negative feedback behavior are related to potentiated brain responses, the opposite is seen for perceptually very similar faces despite generalized emotional responses.