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REVIEW article
Front. Neurosci.
Sec. Autonomic Neuroscience
Volume 18 - 2024 |
doi: 10.3389/fnins.2024.1397300
This article is part of the Research Topic Body Temperature Homeostasis: The Biological Thermostat View all 5 articles
A Review on Targeted Temperature Management for Cardiac Arrest and Traumatic Brain Injury
Provisionally accepted- Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
Therapeutic hypothermia inhibits organ damage by suppressing metabolism, which makes it a therapy of choice for treating various diseases. Specifically, it is often used to treat conditions involving central nervous system disorders where it is expected to positively impact functional prognosis. Although keeping the body temperature at a hypothermic level has been conventionally used, how to manage the body temperature correctly remains a topic of debate. Recently, the concept of temperature management has been proposed to improve the quality of body temperature control and avoid hyperthermia. This review focuses on the effect of temperature on the central nervous system in conditions involving central nervous system disorders and the practice of temperature management in clinical situations. Future research, including novel biomarkers and novel therapies, is also presented.
Keywords: Body Temperature, Hypothermia, Head injury, Cardiac arrest, Central Nervous System
Received: 07 Mar 2024; Accepted: 11 Oct 2024.
Copyright: © 2024 Ito, Hosomi, Nishida, Nakamura, Iba, Ogura and Oda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Sanae Hosomi, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
Takeshi Nishida, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
Youhei Nakamura, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
Jiro Iba, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
Hiroshi Ogura, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
Jun Oda, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
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