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REVIEW article

Front. Neurosci.
Sec. Autonomic Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1397300
This article is part of the Research Topic Body Temperature Homeostasis: The Biological Thermostat View all 5 articles

A Review on Targeted Temperature Management for Cardiac Arrest and Traumatic Brain Injury

Provisionally accepted
Hiroshi Ito Hiroshi Ito Sanae Hosomi Sanae Hosomi *Takeshi Nishida Takeshi Nishida *Youhei Nakamura Youhei Nakamura *Jiro Iba Jiro Iba *Hiroshi Ogura Hiroshi Ogura *Jun Oda Jun Oda *
  • Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

The final, formatted version of the article will be published soon.

    Therapeutic hypothermia inhibits organ damage by suppressing metabolism, which makes it a therapy of choice for treating various diseases. Specifically, it is often used to treat conditions involving central nervous system disorders where it is expected to positively impact functional prognosis. Although keeping the body temperature at a hypothermic level has been conventionally used, how to manage the body temperature correctly remains a topic of debate. Recently, the concept of temperature management has been proposed to improve the quality of body temperature control and avoid hyperthermia. This review focuses on the effect of temperature on the central nervous system in conditions involving central nervous system disorders and the practice of temperature management in clinical situations. Future research, including novel biomarkers and novel therapies, is also presented.

    Keywords: Body Temperature, Hypothermia, Head injury, Cardiac arrest, Central Nervous System

    Received: 07 Mar 2024; Accepted: 11 Oct 2024.

    Copyright: © 2024 Ito, Hosomi, Nishida, Nakamura, Iba, Ogura and Oda. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Sanae Hosomi, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
    Takeshi Nishida, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
    Youhei Nakamura, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
    Jiro Iba, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
    Hiroshi Ogura, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan
    Jun Oda, Department of Traumatology and Acute Critical Medicine, Graduate School of Medicine, Osaka University, Suita, 565-0871, Osaka, Japan

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.