AUTHOR=Fu Jiajia , Lai Xiaohui , Wei Qianqian , Chen Xueping , Shang Huifang 

TITLE=Associations of cerebrospinal fluid profiles with severity and mortality risk of amyotrophic lateral sclerosis

JOURNAL=Frontiers in Neuroscience

VOLUME=18

YEAR=2024

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1375892

DOI=10.3389/fnins.2024.1375892

ISSN=1662-453X

ABSTRACT=<sec id="sec1"><title>Background</title><p>The relationship between routine cerebrospinal fluid (CSF) testing and the disease phenotype of amyotrophic lateral sclerosis (ALS) is unclear, and there are some contradictions in current studies.</p></sec><sec id="sec2"><title>Methods</title><p>This study aimed to analyze the relationship between CSF profiles and disease phenotype in ALS patients. We collected 870 ALS patients and 96 control subjects admitted to West China Hospital of Sichuan University. CSF microprotein, albumin, IgG, index of IgG (IgG<sub>index</sub>), albumin quotient (Q<sub>ALB</sub>), and serum IgG were examined.</p></sec><sec id="sec3"><title>Results</title><p>In ALS patients, CSF IgG, and Q<sub>ALB</sub> were significantly increased, while CSF IgG<sub>index</sub> was decreased, compared with control subjects. Approximately one-third of ALS patients had higher CSF IgG levels. The multiple linear regression analysis identified that CSF IgG<sub>index</sub> was weakly negatively associated with ALS functional rating scale revised (ALSFRS-R) scores (<italic>β</italic> = −0.062, <italic>p</italic> = 0.041). This significance was found in male ALS but not in female ALS. The Cox survival analyses found that upregulated CSF IgG was significantly associated with the increased mortality risk in ALS [HR = 1.219 (1.010–1.470), <italic>p</italic> = 0.039].</p></sec><sec id="sec4"><title>Conclusion</title><p>In the current study, the higher CFS IgG was associated with increased mortality risk of ALS. CSF IgG<sub>index</sub> may be associated with the severity of ALS. These findings may be sex-specific.</p></sec>