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REVIEW article

Front. Neurosci.
Sec. Neuropharmacology
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1341114
This article is part of the Research Topic Novel Therapeutic Target and Drug Discovery for Neurological Diseases, Volume II View all 31 articles

The Multifaceted Role of Quaking Protein in Neuropsychiatric Disorders and Tumor Progression

Provisionally accepted
Zeshang Guo Zeshang Guo 1Bo Liu Bo Liu 1Ying Wei Ying Wei 1Xinyu Hong Xinyu Hong 2*
  • 1 Bethune First Hospital of Jilin University, Changchun, Hebei Province, China
  • 2 Jilin University, Changchun, China

The final, formatted version of the article will be published soon.

    The Quaking protein (QKI) belongs to the STAR protein family and plays a significant role in the development of the nervous system. It serves as a crucial regulator in the processes of tumor progression and cardiovascular system development. Within the central nervous system, QKI has been associated with the onset and progression of numerous neuropsychiatric disorders, including schizophrenia, depression, ataxia, and Alzheimer's disease. In malignant tumors, the methylation of the QKI promoter inhibits its expression. QKI primarily involves in the generation, stability, and selective splicing of non-coding RNA, as well as in mRNA translation. The role of QKI in the tumor microenvironment should not be overlooked. Especially in Glioblastoma Multiforme (GBM), although QKI is not the primary mutation, it still plays a vital role in maintaining the stemness of GBM.However, the mechanisms and further studies on this topic demand extensive basic and clinical trials. signaling pathways. MYB: QKI fusion is commonly observed in AG (Astrocytoma Grade).

    Keywords: Quaking protein, neuropsychiatric disorders, tumor progression, non-coding RNA, Glioblastoma Multiforme

    Received: 19 Nov 2023; Accepted: 11 Jun 2024.

    Copyright: © 2024 Guo, Liu, Wei and Hong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xinyu Hong, Jilin University, Changchun, China

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