AUTHOR=Chapman Tom P. , Farrell Sarah M. , Plaha Puneet , Green Alexander L. , Moosavi Shakeeb H. TITLE=Blunted perception of breathlessness in three cases of low grade insular-glioma JOURNAL=Frontiers in Neuroscience VOLUME=18 YEAR=2024 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1339839 DOI=10.3389/fnins.2024.1339839 ISSN=1662-453X ABSTRACT=
Better understanding of breathlessness perception addresses an unmet clinical need for more effective treatments for intractable dyspnoea, a prevalent symptom of multiple medical conditions. The insular-cortex is predominantly activated in brain-imaging studies of dyspnoea, but its precise role remains unclear. We measured experimentally-induced hypercapnic air-hunger in three insular-glioma patients before and after surgical resection. Tests involved one-minute increments in inspired CO2, raising end-tidal