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ORIGINAL RESEARCH article

Front. Neurosci.
Sec. Translational Neuroscience
Volume 18 - 2024 | doi: 10.3389/fnins.2024.1283518
This article is part of the Research Topic Methods and Applications of Diffusion MRI Tractometry View all 12 articles

Connectomic insights into the impact of 1p/19q co-deletion in dominant hemisphere insular glioma patients

Provisionally accepted
Zuocheng Yang Zuocheng Yang 1Chuan-Dong Yin Chuan-Dong Yin 1Fang-Cheng Yeh Fang-Cheng Yeh 2Bowen Xue Bowen Xue 1Xin-Yu Song Xin-Yu Song 1Gen Li Gen Li 1Zheng-Hai Deng Zheng-Hai Deng 1Shengjun Sun Shengjun Sun 3Zong-Gang Hou Zong-Gang Hou 1Jian Xie Jian Xie 1*
  • 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  • 2 Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States
  • 3 Department of Neuroimaging, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Objectives: This study aimed to elucidate the influences of 1p/19q co-deletion on structural connectivity alterations in patients with dominant hemisphere insular diffuse gliomas.We incorporated 32 cases of left insular gliomas and 20 healthy controls for this study. Using diffusion MRI, we applied correlational tractography, differential tractography, and graph theoretical analysis to explore the potential connectivity associated with 1p/19q co-deletion.The study revealed that the quantitative anisotropy (QA) of key deep medial fiber tracts, including the anterior thalamic radiation, superior thalamic radiation, fornix, and cingulum, had significant negative associations with 1p/19q co-deletion (FDR =4.72×10 -5 ).These tracts are crucial in maintaining the integrity of brain networks. Differential analysis further supported these findings (FWER-corrected p <0.05). The 1p/19q non-co-deletion group exhibited significantly higher clustering coefficients (FDR-corrected p<0.05) and reduced betweenness centrality (FDR-corrected p <0.05) in regions around the tumor compared to HC group. Graph theoretical analysis indicated that non-co-deletion patients had increased local clustering and decreased betweenness centrality in peritumoral brain regions compared to co-deletion patients and healthy controls (FDR-corrected p <0.05).Additionally, despite not being significant through correction, patients with 1p/19q co-deletion exhibited lower trends in weighted average clustering coefficient, transitivity, small worldness, and global efficiency, while showing higher tendencies in weighted path length compared to patients without the co-deletion.The findings of this study underline the significant role of 1p/19q co-deletion in altering structural connectivity in insular glioma patients. These alterations in brain networks could have profound implications for the neural functionality in patients with dominant hemisphere insular gliomas.

    Keywords: Insular gliomas, 1p/19q co-deletion, structural connectivity, Graph theoretical networks, tractography

    Received: 26 Aug 2023; Accepted: 10 Jul 2024.

    Copyright: © 2024 Yang, Yin, Yeh, Xue, Song, Li, Deng, Sun, Hou and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jian Xie, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.