AUTHOR=Hou Kaiying , Liu Tingting , Li Jingwen , Xian Meiyan , Sun Lin , Wei Jianshe 

TITLE=Liquid-liquid phase separation regulates alpha-synuclein aggregate and mitophagy in Parkinson’s disease

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1250532

DOI=10.3389/fnins.2023.1250532

ISSN=1662-453X

ABSTRACT=<p>Parkinson’s disease (PD) is the second most common neurodegenerative disease in the world, and alpha-synuclein (α-syn) abnormal aggregate and mitochondrial dysfunction play a crucial role in its pathological development. Recent studies have revealed that proteins can form condensates through liquid–liquid phase separation (LLPS), and LLPS has been found to be widely present in α-syn aberrant aggregate and mitophagy-related protein physiological processes. This review summarizes the occurrence of α-syn LLPS and its influencing factors, introduces the production and transformation of the related protein LLPS during PINK1-Parkin-mediated mitophagy, hoping to provide new ideas and methods for the study of PD pathology.</p>