AUTHOR=Overk Cassia , Fiorini Emma , Babolin Chiara , Vukicevic Marija , Morici Catherine , Madani Rime , Eligert Valerie , Kosco-Vilbois Marie , Roberts Amanda , Becker Ann , Pfeifer Andrea , Mobley William C. 

TITLE=Modeling Alzheimer’s disease related phenotypes in the Ts65Dn mouse: impact of age on Aβ, Tau, pTau, NfL, and behavior

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1202208

DOI=10.3389/fnins.2023.1202208

ISSN=1662-453X

ABSTRACT=<sec><title>Introduction</title><p>People with DS are highly predisposed to Alzheimer’s disease (AD) and demonstrate very similar clinical and pathological features. Ts65Dn mice are widely used and serve as the best-characterized animal model of DS.</p></sec><sec><title>Methods</title><p>We  undertook studies to characterize age-related changes for AD-relevant markers linked to Aβ, Tau, and phospho-Tau, axonal structure, inflammation, and behavior.</p></sec><sec><title>Results</title><p>We found age related changes in both Ts65Dn and 2N mice. Relative to 2N mice, Ts65Dn mice showed consistent increases in Aβ40, insoluble phospho-Tau, and neurofilament light protein. These changes were correlated with deficits in learning and memory.</p></sec><sec><title>Discussion</title><p>These data have implications for planning future experiments aimed at preventing disease-related phenotypes and biomarkers. Interventions should be planned to address specific manifestations using treatments and treatment durations adequate to engage targets to prevent the emergence of phenotypes.</p></sec>