AUTHOR=Ebersberger Louise , Kratzer Fabian J. , Potreck Arne , Niesporek Sebastian C. , Keymling Myriam , Nagel Armin M. , Bendszus Martin , Wick Wolfgang , Ladd Mark E. , Schlemmer Heinz-Peter , Hoffmann Angelika , Platt Tanja , Paech Daniel 

TITLE=First application of dynamic oxygen-17 magnetic resonance imaging at 7 Tesla in a patient with early subacute stroke

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1186558

DOI=10.3389/fnins.2023.1186558

ISSN=1662-453X

ABSTRACT=<p>Dynamic oxygen-17 (<sup>17</sup>O) magnetic resonance imaging (MRI) is an imaging method that enables a direct and non-invasive assessment of cerebral oxygen metabolism and thus potentially the distinction between viable and non-viable tissue employing a three-phase inhalation experiment. The purpose of this investigation was the first application of dynamic <sup>17</sup>O MRI at 7 Tesla (T) in a patient with stroke. In this proof-of-concept experiment, dynamic <sup>17</sup>O MRI was applied during <sup>17</sup>O inhalation in a patient with early subacute stroke. The analysis of the relative <sup>17</sup>O water (H<sub>2</sub><sup>17</sup>O) signal for the affected stroke region compared to the healthy contralateral side revealed no significant difference. However, the technical feasibility of <sup>17</sup>O MRI has been demonstrated paving the way for future investigations in neurovascular diseases.</p>