AUTHOR=Yu Shoujun , Yue Wenji , Guo Tianruo , Liu Yonghong , Zhang Yapeng , Khademi Sara , Zhou Tian , Xu Zhen , Song Bing , Wu Tianzhun , Liu Fenglin , Tai Yanlong , Yu Xuefei , Wang Hao TITLE=The effect of the subthreshold oscillation induced by the neurons' resonance upon the electrical stimulation-dependent instability JOURNAL=Frontiers in Neuroscience VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1178606 DOI=10.3389/fnins.2023.1178606 ISSN=1662-453X ABSTRACT=

Repetitive electrical nerve stimulation can induce a long-lasting perturbation of the axon's membrane potential, resulting in unstable stimulus-response relationships. Despite being observed in electrophysiology, the precise mechanism underlying electrical stimulation-dependent (ES-dependent) instability is still an open question. This study proposes a model to reveal a facet of this problem: how threshold fluctuation affects electrical nerve stimulations. This study proposes a new method based on a Circuit-Probability theory (C-P theory) to reveal the interlinkages between the subthreshold oscillation induced by neurons' resonance and ES-dependent instability of neural response. Supported by in-vivo studies, this new model predicts several key characteristics of ES-dependent instability and proposes a stimulation method to minimize the instability. This model provides a powerful tool to improve our understanding of the interaction between the external electric field and the complexity of the biophysical characteristics of axons.