AUTHOR=Guo Xiaoming , Wang Dingkun , Ying Caidi , Hong Yuan 

TITLE=Association between brain structures and migraine: A bidirectional Mendelian randomization study

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1148458

DOI=10.3389/fnins.2023.1148458

ISSN=1662-453X

ABSTRACT=<sec><title>Background</title><p>Accumulating evidence of clinical and neuroimaging studies indicated that migraine is related to brain structural alterations. However, it is still not clear whether the associations of brain structural alterations with migraine are likely to be causal, or could be explained by reverse causality confounding.</p></sec><sec><title>Methods</title><p>We carried on a bidirectional Mendelian randomization analysis in order to identify the causal relationship between brain structures and migraine risk. Summary-level data and independent variants used as instruments came from large genome-wide association studies of total surface area and average thickness of cortex (33,992 participants), gray matter volume (8,428 participants), white matter hyperintensities (50,970 participants), hippocampal volume (33,536 participants), and migraine (102,084 cases and 771,257 controls).</p></sec><sec><title>Results</title><p>We identified suggestive associations of the decreased surface area (OR = 0.85; 95% CI, 0.75–0.96; <italic>P</italic> = 0.007), and decreased hippocampal volume (OR = 0.74; 95% CI, 0.55–1.00; <italic>P</italic> = 0.047) with higher migraine risk. We did not find any significant association of gray matter volume, cortical thickness, or white matter hyperintensities with migraine. No evidence supporting the significant association was found in the reverse MR analysis.</p></sec><sec><title>Conclusion</title><p>We provided suggestive evidence that surface area and hippocampal volume are causally associated with migraine risk.</p></sec>