AUTHOR=She Hong-Qing , Sun Yi-Fei , Chen Li , Xiao Qiu-Xia , Luo Bo-Yan , Zhou Hong-Su , Zhou Di , Chang Quan-Yuan , Xiong Liu-Lin TITLE=Current analysis of hypoxic-ischemic encephalopathy research issues and future treatment modalities JOURNAL=Frontiers in Neuroscience VOLUME=17 YEAR=2023 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1136500 DOI=10.3389/fnins.2023.1136500 ISSN=1662-453X ABSTRACT=

Hypoxic-ischemic encephalopathy (HIE) is the leading cause of long-term neurological disability in neonates and adults. Through bibliometric analysis, we analyzed the current research on HIE in various countries, institutions, and authors. At the same time, we extensively summarized the animal HIE models and modeling methods. There are various opinions on the neuroprotective treatment of HIE, and the main therapy in clinical is therapeutic hypothermia, although its efficacy remains to be investigated. Therefore, in this study, we discussed the progress of neural circuits, injured brain tissue, and neural circuits-related technologies, providing new ideas for the treatment and prognosis management of HIE with the combination of neuroendocrine and neuroprotection.