AUTHOR=Arús Bernardo A. , Cosco Emily D. , Yiu Joycelyn , Balba Ilaria , Bischof Thomas S. , Sletten Ellen M. , Bruns Oliver T. 

TITLE=Shortwave infrared fluorescence imaging of peripheral organs in awake and freely moving mice

JOURNAL=Frontiers in Neuroscience

VOLUME=17

YEAR=2023

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2023.1135494

DOI=10.3389/fnins.2023.1135494

ISSN=1662-453X

ABSTRACT=<p>Extracting biological information from awake and unrestrained mice is imperative to <italic>in vivo</italic> basic and pre-clinical research. Accordingly, imaging methods which preclude invasiveness, anesthesia, and/or physical restraint enable more physiologically relevant biological data extraction by eliminating these extrinsic confounders. In this article, we discuss the recent development of shortwave infrared (SWIR) fluorescent imaging to visualize peripheral organs in freely-behaving mice, as well as propose potential applications of this imaging modality in the neurosciences.</p>