AUTHOR=Wu Guode , Li Zhenhua , Li Jing , Li Xin , Wang Manxia , Zhang Jing , Liu Guangyao , Zhang Pengfei 

TITLE=A neglected neurodegenerative disease: Adult-onset globoid cell leukodystrophy

JOURNAL=Frontiers in Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.998275

DOI=10.3389/fnins.2022.998275

ISSN=1662-453X

ABSTRACT=<p>Globoid cell leukodystrophy (GLD), or Krabbe disease (KD) is a rare neurodegenerative disease, and adult-onset GLD is more even neglected by clinicians. This review provides detailed discussions of the serum enzymes, genes, clinical manifestations, neuroimaging features, and therapies of GLD, with particular emphasis on the characteristics of adult-onset GLD, in an attempt to provide clinicians with in-depth insights into this disease.</p>