This article is a correction to:
Gut Bacteria Regulate the Pathogenesis of Huntington’s Disease in Drosophila Model
Anjalika Chongtham1
Jung Hyun Yoo1
Theodore M. Chin1
Ngozi D. Akingbesote1Ainul Huda1J. Lawrence Marsh2
Ali Khoshnan1*- 1Biology and Bioengineering, California Institute of Technology (Caltech), Pasadena, CA, United States
- 2Developmental and Cell Biology, University of California, Irvine, Irvine, CA, United States
A corrigendum on
Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila model
by Chongtham, A., Yoo, J. H., Chin, T. M., Akingbesote, N. D., Huda, A., Marsh, J. L., and Khoshnan, A. (2022). Front. Neurosci. 16:902205. doi: 10.3389/fnins.2022.902205
In the published article, there was an error in Figure 4 as published. We inadvertently duplicated Figure 4A, instead of Figure 4B. The correct figure and its caption appear below.
FIGURE 4
Figure 4. Crocin ameliorates E. coli-induced motor defects and mortality in female FL-HD flies. (A) Freshly eclosed FL-HD flies were treated with rifaximin, luteolin, and crocin for 15 days and their climbing ability was evaluated. Data are reported as mean ± SEM and were analyzed by one-way ANOVA with Tukey's post hoc test. ***p < 0.001, n = 6 groups of 10 flies. (B) Climbing assay was performed to monitor the motor function of flies colonized with crocin, E. coli or E. coli plus crocin. Untreated FL-HD flies were used as control. Data are represented as mean ± SEM and were analyzed by one-way ANOVA with Tukey's post hoc test. ***p < 0.001; **p < 0.01, n = 6 groups of 10 flies. Part (C,D) show the percentage of FL-HD flies, which survived over time (days) under different treatments. Temperature was elevated to 25°C to accommodate E. coli growth. The data are represented as mean ± SEM, two-way ANOVA with Tukey's multiple-comparisons test. ***p < 0.001; **p < 0.01; *p < 0.05, n = 6 groups of 10 flies. (E) Representative confocal images of the GI tract of untreated (control) FL-HD flies or those treated with E. coli (curli) or E. coli plus crocin for 15 days showing bacterial colonization and suppression by crocin treatment. Immunostaining was performed using a monoclonal antibody reactive to E. coli. DAPI was used to stain the nuclei.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: Huntington's disease, microbiota, gut-brain, neurodegeneration, crocin (PubChem CID: 5281233)
Citation: Chongtham A, Yoo JH, Chin TM, Akingbesote ND, Huda A, Marsh JL and Khoshnan A (2022) Corrigendum: Gut bacteria regulate the pathogenesis of Huntington's disease in Drosophila model. Front. Neurosci. 16:991513. doi: 10.3389/fnins.2022.991513
Received: 11 July 2022; Accepted: 30 September 2022;
Published: 13 October 2022.
Edited and reviewed by: Frank Hirth, King's College London, United Kingdom
Copyright © 2022 Chongtham, Yoo, Chin, Akingbesote, Huda, Marsh and Khoshnan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ali Khoshnan, Khoshnan@caltech.edu