AUTHOR=Liu Yonghong , Yue Wenji , Yu Shoujun , Zhou Tian , Zhang Yapeng , Zhu Ran , Song Bing , Guo Tianruo , Liu Fenglin , Huang Yubin , Wu Tianzhun , Wang Hao 

TITLE=A physical perspective to understand myelin II: The physical origin of myelin development

JOURNAL=Frontiers in Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.951998

DOI=10.3389/fnins.2022.951998

ISSN=1662-453X

ABSTRACT=<p>The physical principle of myelin development is obtained from our previous study by explaining Peter’s quadrant mystery: an externally applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E, to explain more phenomena about myelin development systematically. Specifically, the g-ratio and the fate of the Schwann cell’s differentiation are explained in terms of the E-field. Moreover, an experiment is proposed to validate this theory.</p>