AUTHOR=Schalk Gerwin , Worrell Samuel , Mivalt Filip , Belsten Alexander , Kim Inyong , Morris Jonathan M. , Hermes Dora , Klassen Bryan T. , Staff Nathan P. , Messina Steven , Kaufmann Timothy , Rickert Jörn , Brunner Peter , Worrell Gregory A. , Miller Kai J. TITLE=Toward a fully implantable ecosystem for adaptive neuromodulation in humans: Preliminary experience with the CorTec BrainInterchange device in a canine model JOURNAL=Frontiers in Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.932782 DOI=10.3389/fnins.2022.932782 ISSN=1662-453X ABSTRACT=

This article describes initial work toward an ecosystem for adaptive neuromodulation in humans by documenting the experience of implanting CorTec's BrainInterchange (BIC) device in a beagle canine and using the BCI2000 environment to interact with the BIC device. It begins with laying out the substantial opportunity presented by a useful, easy-to-use, and widely available hardware/software ecosystem in the current landscape of the field of adaptive neuromodulation, and then describes experience with implantation, software integration, and post-surgical validation of recording of brain signals and implant parameters. Initial experience suggests that the hardware capabilities of the BIC device are fully supported by BCI2000, and that the BIC/BCI2000 device can record and process brain signals during free behavior. With further development and validation, the BIC/BCI2000 ecosystem could become an important tool for research into new adaptive neuromodulation protocols in humans.