AUTHOR=Luo Wenshu , Cruz-Ochoa Natalia Andrea , Seng Charlotte , Egger Matteo , Lukacsovich David , Lukacsovich Tamás , Földy Csaba TITLE=Pcdh11x controls target specification of mossy fiber sprouting JOURNAL=Frontiers in Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.888362 DOI=10.3389/fnins.2022.888362 ISSN=1662-453X ABSTRACT=
Circuit formation is a defining characteristic of the developing brain. However, multiple lines of evidence suggest that circuit formation can also take place in adults, the mechanisms of which remain poorly understood. Here, we investigated the epilepsy-associated mossy fiber (MF) sprouting in the adult hippocampus and asked which cell surface molecules define its target specificity. Using single-cell RNAseq data, we found lack and expression of