AUTHOR=Liu Zhangdaihong , Whitaker Kirstie J. , Smith Stephen M. , Nichols Thomas E. TITLE=Improved Interpretability of Brain-Behavior CCA With Domain-Driven Dimension Reduction JOURNAL=Frontiers in Neuroscience VOLUME=16 YEAR=2022 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.851827 DOI=10.3389/fnins.2022.851827 ISSN=1662-453X ABSTRACT=

Canonical Correlation Analysis (CCA) has been widely applied to study correlations between neuroimaging data and behavioral data. Practical use of CCA typically requires dimensionality reduction with, for example, Principal Components Analysis (PCA), however, this can result in CCA components that are difficult to interpret. In this paper, we introduce a Domain-driven Dimension Reduction (DDR) method, reducing the dimensionality of the original datasets and combining human knowledge of the structure of the variables studied. We apply the method to the Human Connectome Project S1200 release and compare standard PCA across all variables with DDR applied to individual classes of variables, finding that DDR-CCA results are more stable and interpretable, allowing the contribution of each class of variable to be better understood. By carefully designing the analysis pipeline and cross-validating the results, we offer more insights into the interpretation of CCA applied to brain-behavior data.