AUTHOR=Tang Yizhen , Shah Simran , Cho Kin-Sang , Sun Xinghuai , Chen Dong Feng 

TITLE=Metabolomics in Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Neuroscience

VOLUME=16

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2022.835736

DOI=10.3389/fnins.2022.835736

ISSN=1662-453X

ABSTRACT=<p>Glaucoma is a leading cause of blindness worldwide. It is suggested that primary open angle glaucoma (POAG), the most common form of glaucoma, may be associated with significant metabolic alternations, but the systemic literature review and meta-analysis in the area have been missing. Altered metabolomic profiles in the aqueous humor and plasma may serve as possible biomarkers for early detection or treatment targets. In this article, we performed a systematic meta-analysis of the current literature surrounding the metabolomics of patients with POAG and metabolites associated with the disease. Results suggest several metabolites found to be specifically altered in patients with POAG, suggesting broad generalizability and pathways for future research.</p>