AUTHOR=Spira Micha E. , Erez Hadas , Sharon Aviv 

TITLE=Assessing the Feasibility of Developing in vivo Neuroprobes for Parallel Intracellular Recording and Stimulation: A Perspective

JOURNAL=Frontiers in Neuroscience

VOLUME=15

YEAR=2022

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.807797

DOI=10.3389/fnins.2021.807797

ISSN=1662-453X

ABSTRACT=<p>Developing novel neuroprobes that enable parallel multisite, long-term intracellular recording and stimulation of neurons in freely behaving animals is a neuroscientist’s dream. When fulfilled, it is expected to significantly enhance brain research at fundamental mechanistic levels including that of subthreshold signaling and computations. Here we assess the feasibility of merging the advantages of <italic>in vitro</italic> vertical nanopillar technologies that support intracellular recordings with contemporary concepts of <italic>in vivo</italic> extracellular field potential recordings to generate the dream neuroprobes that read the entire electrophysiological signaling repertoire.</p>