AUTHOR=Jackson Holly , Anzures-Cabrera Judith , Taylor Kirsten I. , Pagano Gennaro , PASADENA Investigators , Prasinezumab Study Group , Altendorf Claudia , Anandan Chareyna , Andrews Giulia , Ansquer Solène , Arrouasse Raphaele , Aslam Sana , Azulay Jean-Philippe , Baker Jeanette , Balaguer Martinez Ernest , Barbu Shadi , Bardram Kara , Bega Danny , Bejr-Kasem Marco Helena , Benatru Isabelle , Benchetrit Eve , Bernhard Felix , Besharat Amir , Bette Sagari , Bichon Amelie , Billnitzer Andrew , Blondeau Sophie , Boraud Thomas , Borngräber Freiderike , Boyd James , Brockmann Kathrin , Brodsky Matthew , Brown Ethan , Bruecke Christof , Calvas Fabienne , Canelo Monica , Carbone Federico , Carroll Claire , Casado Fernandez Laura , Cassé-Perrot Catherine , Castrioto Anna , Catala Helene , Chan Justine , Cheriet Samia , Ciabarra Anthony , Classen Joseph , Coleman Juliana , Coleman Robert , Compta Yaroslau , Corbillé Anne-Gaëlle , Corvol Jean-Christophe , Cosgaya Mariana , Dahodwala Nabila , Damier Philippe , David Elodie , Davis Thomas , Dean Marissa , Debilly Berengere , DeGiorgio Janell , Deik Andres , Delaby Laure , Delfini Marie-Helene , Derkinderen Pascal , Derost Philipp , de Toledo Maria , Deuel Lisa , Marie Diaz-Hernandez Ann , Dietiker Cameron , Dimenshteyn Karina , Dotor Julio , Durif Franck , Ebentheuer Jens , Maria Eggert Karla , Eichau Madueño Sara , Eickhoff Claudia , Ellenbogen Aaron , Ellmerer Philipp , Esparragosa Vazquez Ines , Eusebio Alexandre , Ewert Siobhan , Fang John , Feigenbaum Danielle , Fluchere Frederique , Foubert-Samier Alexandra , Fournier Marie , Fradet Anne , Fraix Valerie , Frank Samuel , Fries Franca , Galitzky Monique , Gallardó Pérez Marisol , Manuel García Moreno Jose , Gasca Carmen , Gasser Thomas , Gibbons Joyce , Giordana Caroline , Gonzalez Martinez Alicia , Goodman Ira , Gorospe Arantza , Goubeaud Marie , Grabli David , Graziella Mangone , Grimaldi Stephan , Gross Jeffrey , Guimaraes-Costa Raquel , Hartmann Andreas , Hartmann Christian , Hassell Travis , Hauser Robert , Hernandez Antonio , Hernandez-Vara Jorge , Hoeglinger Guenter , Homedes Christian , Horta-Barba Andrea , Houeto Jean-Luc , Huebl Julius , Hui Jennifer , Isaacson Stuart , Jankovic Joseph , Janzen Annette , Jauregui Junior , Jiao Jocelyne , Jose Marti Domenech Maria , Joseph Xavier , Kadimi Srinath , Kaminski Pat , Kannenberg Silja , Kassubek Jan , Katz Maya , Klos Kevin , Klos Shannon , Kobet Christopher , Koebert Jennifer , Krause Patricia , Kuehn Andrea , Kulisevsky Bojarsky Jaime , Kumar Rajeev , Kunz Martin , Kurvits Lille , Kwei Kimberly , Laganiere Simon , Laurens Brice , Levin Johannes , Levy Oren , LeWitt Peter , Linazasoro Cristóbal Gurutz , Litvan Irene , Lizarraga Karlo , Longardner Katherine , Lopez Rocio , Lopez Manzanares Lydia , Lucas del Pozo Sara , Rosario Luquin Puido Maria , Luthra Nijee , Lyons Kelly , Maass Sylvia , Machetanz Gerrit , Macias Yolanda , Maltete David , Uriel Manez Miro Jorge , Mariani Louise-Laure , Marin Juan , Marini Kathrin , Marques Ana , Marti Gloria , Jose Marti Domenech Maria , Martinez Saul , Meissner Wassilios , Meoni Sara , Mollenhauer Brit , Mon Martinez Dunia , Moon Johnson , Moro Elena , Morrison Peter , Muehlberg Christoph , Multani Manpreet , Murphy Christine , Nicholas Anthony , Pahwa Rajesh , Palasi Antonio , Pape Heidi , Patel Neepa , Patel Prity , Peball Marina , Peckham Elizabeth , Peery Terry , Perez Rafael , Perez Jesus , Petit Alisa , Pinkhardt Elmar , Poewe Werner , Pomies Elsa , Preterre Cecile , Quinn Joseph , Rascol Olivier , Remy Philippe , Richard Irene , Roeben Benjamin , Ruether Emily , Rumpf Jost-Julian , Russell David , Salhi Hayet , Samaniego-Toro Daniela , Samier-Foubert Alexandra , Sanchez Antonio , Schmitt Emmanuelle , Schnitzler Alfons , Schorr Oliver , Schwartzbard Julie , Schweyer Kerstin , Seppi Klaus , Sergo Victoria , Shill Holly , Siderowf Andrew , Simuni Tanya , Spampinato Umberto , Sriram Ashok , Stover Natividad , Tanner Caroline , Tarakad Arjun , Taylor Carolyn , Thalamus Claire , Toothaker Thomas , Van Blercom Nadege , Vanegas-Arrogave Nora , Vela Lydia , Vergnet Sylvian , Vidal Tiphaine , Vöglein Jonathan , Walsh Ryan , Waters Cheryl , Wegscheider Mirko , Weidinger Endy , Weill Caroline , Wenzel Gregor , Witjas Tatiana , Wurster Isabel , Wright Brenton , Zimmermann Milan , Zuzuarregui Rafael , Abt Markus , Bamdadian Atieh , Barata Teresa , Barbet Nicholas , Belli Sara , Boess Frank , Bonni Azad , Borroni Edilio , Boulay Anne , Britschgi Markus , Chague Jerome , Cosson Valerie , Czech Christian , Deptula Dennis , Diack Cheikh , Doody Rachelle , Dukart Juergen , D’Urso Giulia , Dziadek Sebastian , Eddleston Hannah , Edgar Chris , Essioux Laurent , Farell Morgan , Finch Rebecca , Fontoura Paulo , Gruenbauer Waltraud , Hahn Andrea , Holiga Stefan , Honer Michael , Jadidi Shirin , Johnson-Wood Kelly , Keller Markus , Kilchenmann Timothy , Koller Martin , Kremer Thomas , Kustermann Thomas , Landsdall Claire , Lindemann Michael , Lipsmeier Florian , Luzy Cecile , Manchester Marianne , Marchesi Maddalena , Martenyi Ferenc , Martin-Facklam Meret , Mironova Katerina , Monnet Annabelle , Moore Emma , K Ness Daniel , Niggli Markus , Nikolcheva Tania , Ostrowitzki GP Susanne , Passmard Benedicte , Poirier Agnes , Post Anke , Prasad Megana , Pross Nathalie , Quock Tiffany , Ricci Benedicte , Rose Ellen , Sarry Christoph , Schubert Christine , Selkoe Dennis , Sevigny Jeff , Sink Kaycee , Staunton Hannah , Steven Tim , Strasak Alexander , Svoboda KT Hanno , Tripuraneni Radhika , Trundell Dylan , Umbricht Daniel , Verselis Lynne , Vogt Annamarie , Volkova-Volkmar Ekaterina , Weber Cornelia , Weber Silke , Zago Wagner TITLE=Hoehn and Yahr Stage and Striatal Dat-SPECT Uptake Are Predictors of Parkinson’s Disease Motor Progression JOURNAL=Frontiers in Neuroscience VOLUME=15 YEAR=2021 URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.765765 DOI=10.3389/fnins.2021.765765 ISSN=1662-453X ABSTRACT=

Currently, no treatments available for Parkinson’s disease (PD) can slow PD progression. At the early stage of the disease, only a subset of individuals with PD progress quickly, while the majority have a slowly progressive form of the disease. In developing treatments that aim to slow PD progression, clinical trials aim to include individuals who are likely to progress faster, such that a treatment effect, if one exists, can be identified easier and earlier. The aim of the present study was to identify baseline predictors of clinical progression in early PD. We analyzed 12-month data acquired from the PASADENA trial Part 1 (NCT03100149, n = 76 participants who were allocated to the placebo arm and did not start symptomatic therapy) and the Parkinson’s Progression Markers Initiative (PPMI) study (n = 139 demographically and clinically matched participants). By using ridge regression models including clinical characteristics, imaging, and non-imaging biomarkers, we found that Hoehn and Yahr stage and dopamine transporter single-photon emission computed tomography specific binding ratios (Dat-SPECT SBR) in putamen ipsilateral to the side of motor symptom onset predicted PD progression at the early stage of the disease. Further studies are needed to confirm the validity of these predictors to identify with high accuracy individuals with early PD with a faster progression phenotype.