AUTHOR=Zhang Yanqiu , Zhang Mohan , Ling Zichao , Wang Peiguo , Jian Xiqi 

TITLE=The Influence of Transcranial Magnetoacoustic Stimulation Parameters on the Basal Ganglia-Thalamus Neural Network in Parkinson’s Disease

JOURNAL=Frontiers in Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.761720

DOI=10.3389/fnins.2021.761720

ISSN=1662-453X

ABSTRACT=<p><bold>Objective:</bold> Parkinson’s disease (PD) is a degenerative disease of the nervous system that frequently occurs in the aged. Transcranial magnetoacoustic stimulation (TMAS) is a neuronal adjustment method that combines sound fields and magnetic fields. It has the characteristics of high spatial resolution and noninvasive deep brain focusing.</p><p><bold>Methods:</bold> This paper constructed a simulation model of TMAS based on volunteer’s skull computer tomography, phased controlled transducer and permanent magnet. It simulates a transcranial focused sound pressure field with the Westervelt equation and builds a basal ganglia and thalamus neural network model in the PD state based on the Hodgkin-Huxley model.</p><p><bold>Results:</bold> A biased sinusoidal pulsed ultrasonic TMAS induced current with 0.3 T static magnetic field induction and 0.2 W⋅cm<sup>–2</sup> sound intensity can effectively modulate PD states with RI ≥ 0.633. The magnitude of magnetic induction strength was changed to 0.2 and 0.4 T. The induced current was the same when the sound intensity was 0.4 and 0.1 W⋅cm<sup>–2</sup>. And the sound pressure level is in the range of −1 dB (the induced current difference is less than or equal to 0.019 μA⋅cm<sup>–2</sup>). TMAS with a duty cycle of approximately 50% can effectively modulates the error firings in the PD neural network with a relay reliability not less than 0.633.</p><p><bold>Conclusion:</bold> TMAS can modulates the state of PD.</p>