AUTHOR=Zheng Kangyong , Chen Changcheng , Yang Suyong , Wang Xueqiang 

TITLE=Aerobic Exercise Attenuates Pain Sensitivity: An Event-Related Potential Study

JOURNAL=Frontiers in Neuroscience

VOLUME=15

YEAR=2021

URL=https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2021.735470

DOI=10.3389/fnins.2021.735470

ISSN=1662-453X

ABSTRACT=<p>In this study, electroencephalography (EEG) was utilized to explore the neurophysiological mechanisms of aerobic exercise-induced hypoalgesia (EIH) and provide a theoretical basis for the application of aerobic exercise in pain assessment and treatment. Forty-five healthy subjects were randomly divided into moderate-intensity aerobic exercise [70% heart rate reserve (HRR)], low-intensity aerobic exercise (50% HRR), or control groups (sitting). Aerobic exercise was performed with cycling. Pressure pain threshold (PPT), heat pain threshold (HPT), event-related potential (ERP) induced by contact heat stimulus and pain scoring were measured before and after the intervention. We found that moderate-intensity aerobic exercise can increase the PPT (rectus femoris: <italic>t</italic> = −2.71, <italic>p</italic> = 0.017; tibialis anterior muscle: <italic>t</italic> = −2.36, <italic>p</italic> = 0.033) and HPT (tibialis anterior muscle: <italic>t</italic> = −2.219, <italic>p</italic> = 0.044) of proximal intervention sites rather than distal sites, and decreased pain scorings of contact heat stimulus. After moderate-intensity aerobic exercise, alpha oscillation power reflecting the central descending inhibitory function was enhanced (<italic>t</italic> = −2.31, <italic>p</italic> &lt; 0.05). Low-intensity aerobic exercise mainly reduced the pain unpleasantness rating (Block 1: <italic>t</italic> = 2.415, <italic>p</italic> = 0.030; Block 2: <italic>t</italic> = 3.287, <italic>p</italic> = 0.005; Block 4: <italic>t</italic> = 2.646, <italic>p</italic> = 0.019; Block 5: <italic>t</italic> = 2.567, <italic>p</italic> = 0.022). Aerobic exercise had an overall EIH effect. Its hypoalgesic effect was related to exercise intensity and affected by the site and type of pain stimulus. Moderate-intensity aerobic exercise effectively reduced the sensitivity to various painful stimuli, and low-intensity aerobic exercise selectively inhibited the negative emotional pain response. The hypoalgesic mechanism of aerobic exercise involves the enhancement of the central descending inhibitory function.</p>